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目的:探讨降低非浸润性膀胱移行细胞癌经尿道手术后复发率的有效方法。方法:1995年1月~2002年12月205例非浸润性膀胱移行细胞癌患者,行经尿道膀胱肿瘤切除术后膀胱灌注治疗预防复发。单纯以丝裂霉素30 mg膀胱灌注(A组)120例;以丝裂霉素30 mg膀胱灌注,联合肌注白介素-2和γ-干扰素(B组)85例。比较两组随访期内复发率。结果:所有患者均随访2年以上,A组膀胱癌的复发率为42.5%,B组复发率为25.9%(P<0.01)。结论:丝裂霉素膀胱灌注联合肌注白介素-2和γ-干扰素能有效降低非浸润性膀胱移行细胞癌的复发率。
Objective: To explore an effective method to reduce the recurrence rate of non-invasive bladder transitional cell carcinoma after transurethral resection. METHODS: From January 1995 to December 2002, 205 patients with non-invasive bladder transitional cell carcinoma underwent bladder irrigation after transurethral resection of bladder tumor to prevent recurrence. 120 cases were treated with intravesical instillation of mitomycin 30 mg alone (group A), and 85 cases were given intravesical instillation of mitomycin 30 mg combined with intramuscularly injected IL-2 and IFN-γ (group B). The recurrence rate was compared between the two groups during the follow-up period. Results: All patients were followed up for more than 2 years. The recurrence rate of bladder cancer in group A was 42.5% and that in group B was 25.9% (P <0.01). CONCLUSION: Mitomycin intravesical instillation combined with intramuscular injection of IL-2 and IFN-γ can effectively reduce the recurrence rate of non-invasive bladder transitional cell carcinoma.