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组成核糖体相关复合物的MPP11和HSPA14,因其能够辅助“伴侣分子”完成新生肽链在核糖体从最初合成的线性结构到组装、正确折叠成三维构象的过程,又被称为“辅助伴侣”分子。近年来的研究表明,MPP11和HSPA14不仅能够发挥其“辅助伴侣”分子作用,也与细胞分化发育以及肿瘤发生发展存在紧密联系。本文通过就MPP11和HSPA14分子的结构、细胞内定位、生物学功能以及它们之间的相互作用、相互调控等方面进行综述,进一步揭示MPP11和HSPA14在肿瘤中的高表达,介导了肿瘤的发生发展过程,为后续肿瘤免疫治疗提供了新的方向。
The MPP11 and HSPA14, which constitute the ribosome-related complexes, are also known as the “complementary molecules” that can assist the “partner molecule” to complete the process of nascent peptide synthesis from the initially synthesized linear structure of the ribosome to the correct folding into a three-dimensional conformation. “Assist companion” molecule. In recent years, studies have shown that MPP11 and HSPA14 not only can exert their “assistant mate” molecular role, but also closely related to cell differentiation and tumor development. This article reviews the structure, intracellular localization, biological functions of MPP11 and HSPA14 molecules, their interactions, and their interactions with each other, and further reveals that MPP11 and HSPA14 are highly expressed in tumors and mediate tumorigenesis. The development process provides a new direction for follow-up tumor immunotherapy.