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目的 研究霉酚酸酯 (MMF)对大鼠角膜移植排斥反应的防治作用。方法 建立大鼠穿透性角膜移植排斥反应的动物模型 ,观察MMF对大鼠角膜移植片存活的影响 ,并与阴性对照组和CsA治疗组相比较。结果 阴性对照组角膜植片平均存活时间为 11 375± 1 6 85天 ,CsA治疗组为 18 6 2 5± 1 5 98天 ,MMF治疗组为 16 5 0 0± 1 85 2天 ,CsA +MMF组为 2 4 5 0 0±1 773天 ,均比阴性对照组显著延长。结论 MMF对大鼠穿透性角膜移植排斥反应具有抑制作用 ,显著地延长角膜植片的存活时间。
Objective To study the preventive and therapeutic effects of mycophenolate mofetil (MMF) on the rejection of rat corneal allografts. Methods The rat model of penetrating keratoplasty rejection was established. The effect of MMF on the survival of rat corneal graft was observed and compared with the negative control group and CsA treatment group. Results The mean corneal graft survival time was 11 375 ± 1685 days in the negative control group, 18 62 5 ± 158 98 days in the CsA treated group, 165 00 ± 1 852 days in the MMF treated group, and CsA + MMF Group was 2450 ± 1 773 days, significantly longer than the negative control group. Conclusion MMF can inhibit the rejection of penetrating keratoplasty rats and prolong the survival time of corneal graft significantly.