本文报导古尼拟青霉诱生及促诱生干扰素的实验研究。以VSV为攻击病毒,人羊膜细胞FL株为测定细胞,结果显示古尼拟青霉提取液可诱导产生干扰素。一定浓度范围内,诱生能力随浓度增加而增强。诱生动态试验表明,2h即可出现较低效价干扰素,6h达最大值并持续到12h。如先用NDV-F处理FL细胞1h再加提取液,可将其诱生产量由4000IU/ml提高到8000IU/ml。 This article reports the experimental study of the induction and provocation of interferon by Penicillium geninicus. Using VSV as the challenge virus and human amniotic FL cells as the assay cells, it was shown that the extract of Penicillium genitestus can induce interferon production. Within a certain concentration range, the ability to induce increases with increasing concentrations. The induced dynamic test showed that the lower titer interferon appeared at 2 h and reached its maximum at 6 h and lasted to 12 h. If the FL cells were first treated with NDV-F for 1 h and then the extract was added, the induced production could be increased from 4000 IU/ml to 8000 IU/ml.