论文部分内容阅读
药理学上致力于预防和治疗出血性静脉曲张的药物应能减少门脉压至不出血的水平。血管收缩剂内脏血管收缩剂减少胃食管侧支血流和压力,能逆转可导致门脉高压的升高的门脉血流。加压素临床应用的加压素根据氨基酸组成不同,有赖氨酸加压素和精氨酸加压素。动物研究表明,加压素减少血流的效应有剂量依赖性。临床已应用的剂量在每分钟0.1～1.0U之间,但尚未进行过剂量-效应研究,因为加压素即使短期应用对人体也可产生严重副作用。最严重的副作用与其血管收缩效果和降低心搏量有关,可增加心脏后负荷,产生压力感受器调停的心动徐缓,减少冠脉血流,直接损害心脏收缩力,也有报告引
Pharmacologically pharmacological efforts to prevent and treat hemorrhagic varices should reduce portal pressure to non-hemorrhagic levels. Vasoconstrictor vasoconstrictors reduce gastroesophageal collateral flow and pressure and reverse the increased portal blood flow that can lead to portal hypertension. Vasopressin clinical application of vasopressin according to different amino acid composition, with vasopressin and arginine vasopressin. Animal studies have shown that vasopressin reduces blood flow in a dose-dependent manner. Clinical doses have been applied at between 0.1 and 1.0 U per minute, but no dose-response studies have been conducted because vasopressin can have serious side effects on humans even for short-term use. The most serious side effects associated with vasoconstrictor effects and reduced stroke volume may increase cardiac postload, resulting in bradycardia mediated by baroreceptors, reducing coronary blood flow, and directly impairing cardiac contractility, as well as reports