论文部分内容阅读
背景与目的:维吾尔族有着不同于汉族的遗传背景,目前国内对维吾尔族女性散发性乳腺癌组织中BRCA1、C-erBb-2的研究少有报道。本研究旨在探讨BRCA1、C-erBb-2在新疆维吾尔族女性散发性乳腺癌中的表达特点及其临床意义。方法:应用组织芯片技术及免疫组织化学方法检测190例新疆维吾尔族女性乳腺癌组织中BRCA1、C-erBb-2的表达,以100例汉族女性乳腺癌及30例维吾尔族女性乳腺良性肿瘤患者作为对照,分析二者表达的特点和相关性及其与临床病理参数间的关系。结果:新疆维吾尔族、汉族女性散发性乳腺癌组织和维吾尔族女性良性乳腺疾病组织中BRCA1表达阳性率分别为62.1%、28.9%和86.7%,维、汉两民族女性乳腺癌组间差异有统计学意义(P<0.05);维吾尔族女性与汉族女性散发性乳腺癌组织中C-erBb-2的阳性表达差异无统计学意义(26.0%:22.0%,P>0.05);蛋白表达相关分析显示维、汉两民族女性乳腺癌组织中C-erBb-2的表达和BRCA1的表达呈负相关关系(P<0.05);维吾尔族女性散发性乳腺癌组织中BRCA1阳性表达与肿瘤分期、淋巴结转移情况有关(P<0.05);C-erBb-2在肿瘤大小、肿瘤分期、淋巴结转移情况、PR状况方面其阳性表达之间差异有统计学意义(P<0.05)。结论:新疆地区维、汉女性散发性乳腺癌及维吾尔族女性乳腺良性肿瘤组织中BRCA1和C-erBb-2表达均存在显著差异,且维、汉女性乳腺癌组织中BRCA1的阳性表达显示有种族差异性,临床常规联合监测BRCA1和C-erBb-2,有助于指导患者合理治疗和评价预后。
BACKGROUND & OBJECTIVE: Uygur nationality has a genetic background different from that of Han nationality. At present, few reports have been reported on BRCA1 and C-erBb-2 in Uyghur women with sporadic breast cancer. This study aimed to investigate the expression of BRCA1 and C-erBb-2 in sporadic breast cancer in Uighur women in Xinjiang and its clinical significance. Methods: The expression of BRCA1 and C-erBb-2 in 190 cases of Uyghur women with breast cancer were detected by tissue microarray and immunohistochemistry. 100 female Han women and 30 Uyghur women with benign breast cancer were enrolled as Control, analysis of the characteristics of the two expression and its relationship with clinicopathological parameters. Results: The positive rates of BRCA1 expression in Uygur and Han women with sporadic breast cancer and in Uyghur women with benign breast disease were 62.1%, 28.9% and 86.7%, respectively. The difference between the two groups was statistically significant significance (P <0.05); there was no significant difference in expression and Han female women between sporadic breast tissue of C-erBb-2 (26.0%: 22.0%, P> 0.05); protein expression analysis dimension, and Han female breast cancer tissue and expression of BRCA1 C-erBb-2 was negatively correlated (P <0.05); Uygur female BRCA1 sporadic breast tissue expression and tumor stage, lymph node metastasis (P <0.05). The positive expression of C-erBb-2 in tumor size, tumor stage, lymph node metastasis and PR status had statistical significance (P <0.05). CONCLUSION: There are significant differences in the expression of BRCA1 and C-erBb-2 between female Han and female Uighur women with breast cancer in Uygur and Han nationality in Xinjiang region, and the positive expression of BRCA1 in Uygur and Han women with breast cancer Differences, clinical routine monitoring of BRCA1 and C-erBb-2, helps to guide patients to rational treatment and evaluation of prognosis.