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目的观察阿托伐他汀及低分子肝素钙对高脂血症并高凝状态的疗效。方法对46例高脂血症合并血液高凝状态患者在常规治疗基础上加用阿托伐他汀及低分子肝素钙治疗,比较治疗前后血脂各项指标及凝血功能(TT、PT、APTT、FIB)、D二聚体(D-D)及血小板(PLT)变化。结果治疗前后血脂各项指标有明显改变,降低总胆固醇的总有效率达95.6%,降低甘油三酯的总有效率为84.8%,且治疗后FIB、D-D明显降低,TT、PT、APTT及PLT无明显变化。结论阿托伐他汀及低分子肝素钙对高脂血症并高凝状态有较好的疗效,能有效降低血脂(总胆固醇和甘油三酯),改善血液高凝状态,副作用较少,是目前治疗高脂血症并高凝状态较好的方法。
Objective To observe the effect of atorvastatin and low molecular weight heparin on hyperlipidemia and hypercoagulability. Methods 46 patients with hyperlipidemia and hypercoagulable state were treated with atorvastatin and low molecular weight heparin calcium on the basis of routine treatment. The indexes of blood lipid and blood coagulation (TT, PT, APTT, FIB ), D dimer (DD) and platelet (PLT). Results Before and after treatment, the indexes of blood lipids were significantly changed, the total effective rate of lowering total cholesterol was 95.6%, the total effective rate of lowering triglycerides was 84.8%, and the FIB, DD, TT, PT, APTT and PLT No significant changes. Conclusions Atorvastatin and low molecular weight heparin calcium have a good curative effect on hyperlipidemia and hypercoagulable state, which can effectively reduce blood lipid (total cholesterol and triglyceride), improve blood hypercoagulability with less side effects Treatment of hyperlipidemia and hypercoagulable state better method.