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目的了解乐东县恶性疟原虫对抗疟药的敏感情况,以指导用药。方法采用Rieckmann体外微量法,于1999年测定氯喹、哌喹、咯萘啶、青蒿琥酯、双氢青蒿素及其加用氯喹的敏感性。结果测定上述药物的ID50依次为244nmol/L、464nmol/L、71nmol/L、3nmol/L、4nmol/L与11/1.32nmol/L。完全抑制裂殖体形成的平均浓度(CIMC)依次为353nmol/L、672nmol/L、102nmol/L、10nmol/L、13nmol/L与19/1.86nmol/L。前3种药的抗性率依次为85.71%、42.86%与14.29%。结论恶性疟原虫对氯喹、哌喹、咯萘啶产生抗性,对青蒿琥酯与双氢青蒿素均敏感,氯喹与双氢青蒿素联用体外测定有增效作用。
Objective To understand the susceptibility of Plasmodium falciparum to antimalarial drugs in Ledong County to guide the medication. Methods The Rieckmann in vitro microdialysis method was used to determine the sensitivity of chloroquine, piperaquine, pyronaridine, artesunate, dihydroartemisinin and chloroquine in 1999. Results ID50 values of the above drugs were 244 nmol / L, 464 nmol / L, 71 nmol / L, 3 nmol / L, 4 nmol / L and 11 / 1.32 nmol / L, respectively. The mean concentration of complete inhibition of schizont formation (CIMC) was 353 nmol / L, 672 nmol / L, 102 nmol / L, 10 nmol / L, 13 nmol / L and 19 / 1.86 nmol / L, respectively. The resistance rates of the first three drugs were 85.71%, 42.86% and 14.29%, respectively. Conclusion Plasmodium falciparum is resistant to chloroquine, piperacillin and pyronaridine, and both of them are sensitive to artesunate and dihydroartemisinin. Chloroquine and dihydroartemisinin have synergistic effect in vitro.