目的探讨胃镜下喷洒生物蛋白胶治疗十二指肠球部溃疡并出血的疗效。方法将158例无严重并发症的十二指肠球部溃疡并出血的患者随机分为研究组和对照组两组,治疗组溃疡局部喷洒生物蛋白胶+常规治疗,对照组常规治疗,比较两组疗效。结果治疗组患者止血时间、再出血率、输血量和手术率明显示低于对照组(P<0.05),两组住院总费用无明显差异(P>0.05)。结论胃镜下喷洒生物蛋白胶治疗十二指肠球部溃疡并出血成功率高,止血效果明显,预后较好。 Objective To investigate the curative effect of spraying bioprotein glue under endoscopy on duodenal ulcer and bleeding. Methods 158 cases of duodenal ulcer without serious complications and bleeding were randomly divided into two groups: study group and control group. The treatment group was treated with local application of bioprotein gel and conventional treatment, while the control group received conventional treatment. Group efficacy. Results The hemostasis time, rebleeding rate, blood transfusion and operation rate in the treatment group were significantly lower than those in the control group (P <0.05). There was no significant difference in the total hospitalization costs between the two groups (P> 0.05). Conclusion Gastroscopy sprayed with bioprotein gel treatment of duodenal ulcer with high success rate of hemorrhage, bleeding effect is obvious, the prognosis is good.