肿瘤坏死因子样配体1A(TL1A)作为新发现的肿瘤坏死因子超家族成员,通过与其受体死亡受体3或诱骗受体3结合,为激活T淋巴细胞提供协同刺激信号。TL1A具有诱导细胞凋亡、增加辅助性T细胞因子分泌的生理学活性,在淋巴细胞的活化、炎症反应的调节及炎性肠病、动脉粥样硬化等发生发展中起重要作用。 Tumor necrosis factor-like ligand 1A (TL1A), as a newly discovered member of the tumor necrosis factor superfamily, provides a costimulatory signal for activating T lymphocytes by binding to its receptor death receptor 3 or decoy receptor 3. TL1A has the physiological activity of inducing apoptosis and increasing the secretion of helper T-cells, playing an important role in the activation of lymphocytes, the regulation of inflammatory reaction, the development of inflammatory bowel disease and atherosclerosis.