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本文对47例原发性肾病综合征患儿进行血清涎酸测定,结果:肾炎性肾病和单纯性肾病患儿肾病期血清SA 显著升高,分别达893.2±209.4mg/L 和749.9±208.6mg/L,而前者又显著高于后者。单纯性肾病缓解期血清SA 为491.3±186.9mg/L,同对照组(415.2±144.9mg/L)比较无明显差异。此外,血SA 上升显著者激素反应差;血SA 水平与血沉和血清蛋白电泳中α_2球蛋白百分比呈正相关。研究提示肾病综合征肾病期患儿血清SA 浓度明显升高,其变化可反映激素治疗的近期疗效。
Serum sialic acid was measured in 47 children with primary nephrotic syndrome. Results Serum SA was significantly increased in nephropathy patients with nephritis and nephropathy (893.2 ± 209.4 mg / L and 749.9 ± 208.6 mg, respectively) / L, while the former is significantly higher than the latter. Serum SA was 491.3 ± 186.9mg / L in remission stage of simple nephrotic syndrome, there was no significant difference with the control group (415.2 ± 144.9mg / L). In addition, significant increase in serum SA hormone response is poor; blood SA levels and serum hemoglobin electrophoresis and α 2 globulin percentage was positively correlated. Research suggests that nephrotic syndrome in children with renal disease serum SA concentrations were significantly increased, the changes reflect the short-term effect of hormone therapy.