在复合催化剂作用下,3-氯-1,2-丙二醇与氨水作用生成缩水甘油中间体,后者与不同的胺化试剂进行催化开环合成了标题化合物,比较相关文献,收率分别提高10%以上。该过程实现了“一锅法”合成,路线简便易行,易于控制。合成的目标产物减压蒸馏纯化后,经液相色谱检测纯度>99.0%,通过FT-IR,1HNMR,13CNMR,MS表征了其结构。 Under the action of the composite catalyst, 3-chloro-1,2-propanediol reacted with ammonia to form a glycidyl intermediate, which was subjected to catalytic ring-opening with different amination reagents to synthesize the title compound. The relative literatures were compared and the yield was increased by 10 %the above. This process has realized “one pot method” synthesis, the route is simple and easy to control. After the target product was purified by vacuum distillation, the purity was> 99.0% by liquid chromatography and its structure was characterized by FT-IR, 1HNMR, 13CNMR and MS.