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目的 为了增加阿昔洛韦在皮肤中的滞留量 ,提高局部生物利用度 ,制备了阿昔洛韦棕榈酸酯脂质体凝胶剂。研究其质量控制 ,进行稳定性考察。方法 采用均匀设计法筛选最佳处方 ,以SephadexG - 5 0柱测定脂质体的包封率和制剂的渗漏率 ,观察脂质体的外观形态。结果 脂质体凝胶剂为乳白色 ,脂质体平均包封率为 95 .1% ,平均粒径为 30 0nm ,对光、湿度稳定性好 ,但受温度影响较大。结论 该脂质体凝胶剂制备工艺可行 ,质量稳定 ,检测方法可靠 ,可满足临床需要
Objective In order to increase the retention of acyclovir in the skin and improve the local bioavailability, acyclovir palmitate liposome gel was prepared. Study its quality control, stability study. Methods The optimal prescriptions were screened by uniform design. The encapsulation efficiency and the leakage rate of the liposomes were determined by Sephadex G - 50 column. The appearance and appearance of the liposomes were observed. Results The liposome gel was milky white. The average entrapment efficiency of liposome was 95.1% and the average particle size was 30 0 nm. The liposome gel had good stability to light and humidity but was greatly affected by temperature. Conclusion The liposome gel preparation process is feasible, stable quality, reliable detection method to meet the clinical needs