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目的：了解难治性抑郁症专业治疗中展开无抽搐电休克疗法的临床有效性。方法：随机抽选94例因患难治性抑郁症而于2015年01月-2016年12月进入本院的患者，参照两种疗法展开随机分组：45例Ⅰ组内施以保守疗法，49例Ⅱ组内则施以无抽搐电休克技术，同时给予两组疗效及其HAMD计分展开比较。结果：45例Ⅰ组内总有效率51.11%（23/45），49例Ⅱ组为75.51%（37/49），（P＜0.05）；Ⅱ组HAMD计分明显比Ⅰ组低，（P＜0.05）。结论：临床对难治性抑郁症患者展开专业治疗时，选择无抽搐电休克技术实践价值高，推荐选用。“,”Objective:To understand the treatment-resistant depression professional treatment of no tic electroconvulsive therapy of clinical efcacy. Methods:Randomly selected94 cases of treatment-resistant depression and in January2015 - December2016 in our hospital patients with reference to the two treatments on random grouping:45 casesⅠ to conservative treatment in the group,49 casesⅡ group tends to no tic electric shock technology, at the same time to compare two groups of curative efect and the HAMD score. Results:45 casesⅠ group total efective rate was51.11% (23/45),49 casesⅡ group was 75.51% (37/49), (P <0.05); HAMD scoreⅡ group was obviously lower thanⅠ group, (P <0.05).Conclusion:Clinical professional treatment on patients with treatment-resistant depression, choose no tic electric shock technology high practical value, recommended to choose.