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目的:探讨反复自然流产患者主动免疫治疗的妊娠结局。方法:将2001年3月～2007年5月经主动免疫治疗成功的102例反复自然流产患者作为研究对象,对其妊娠结局进行回顾性分析。结果:RSA组妊娠期疾病4例,其中妊娠期高血压3例,发生率3.9%(4/102),妊娠期糖尿病1例;正常生育组妊娠期疾病5例,发生率4.5%(5/110);两组胎膜早破、胎儿生长受限、早产发生率比较差异均无统计学意义(P>0.05);RSA组剖宫产率(56.9%)明显高于正常生育组(41.8%)(P<0.01);两组分娩出血量差异无统计学意义(P>0.05);RSA组与正常生育组子代在性别比、出生体重、Apgar评分、新生儿病率等方面差异无统计学意义(P>0.05);RSA组子代出生缺陷发生率明显高于正常生育组(P<0.05)。结论:主动免疫治疗对于反复自然流产患者妊娠结局影响较小,可以进一步推广。
Objective: To investigate the pregnancy outcome of spontaneous immunotherapy in patients with recurrent spontaneous abortion. Methods: From March 2001 to May 2007, 102 patients with recurrent spontaneous abortion, who were successfully treated by active immunotherapy, were included in this study. The pregnancy outcome was retrospectively analyzed. Results: In the RSA group, there were 4 cases of gestational diseases including 3 cases of gestational hypertension, the incidence of which was 3.9% (4/102) and 1 case of gestational diabetes mellitus (1 case). The incidence of gestational diseases in normal group was 5 (4.5% 110). There was no significant difference in the incidence of premature rupture of membranes, fetal growth restriction and preterm delivery between two groups (P> 0.05). The rate of cesarean section in RSA group (56.9%) was significantly higher than that in normal fertility group (41.8% ) (P <0.01). There was no significant difference in the amount of hemorrhage between the two groups (P> 0.05). There was no significant difference in the sex ratio, birth weight, Apgar score and neonatal morbidity between the RSA group and the normal fertility group (P> 0.05). The incidence of birth defects in progeny of RSA group was significantly higher than that of normal fertility group (P <0.05). Conclusion: Active immunotherapy has little effect on pregnancy outcome in patients with recurrent spontaneous abortion and can be further popularized.