This paper presents an adaptive method to solve the robust fault-tolerant control (FTC) problem for a class of large scale systems against actuator failures and lossy interconnection links. In terms of the special distributed architectures, the adaptation laws are proposed to estimate the unknown eventual faults of actuators and interconnections, constant external disturbances, and controller parameters on-line. Then a class of distributed state feedback controllers are constructed for automatically compensating the fault and disturbance effects on systems based on the information from adaptive schemes. On the basis of Lyapunov stability theory, it shows that the resulting adaptive closed-loop large-scale system can be guaranteed to be asymptotically stable in the presence of uncertain faults of actuators and interconnections, and constant disturbances. The proposed design technique is finally evaluated in the light of a simulation example. This paper presents an adaptive method to solve the robust fault-tolerant control (FTC) problem for a class of large scale systems against actuator failures and lossy interconnection links. In terms of the special distributed architectures, the adaptation laws are proposed to estimate the unknown Eventual faults of actuators and interconnections, constant external disturbances, and controller parameters on-line. Then a class of distributed state feedback controllers are constructed for automatically compensating the fault and disturbance effects on systems based on the information from adaptive schemes. On the basis of Lyapunov stability theory, it shows that resulting adaptive closed-loop large-scale system can be guaranteed to be asymptotically stable in the presence of uncertain constants of actuators and interconnections, and constant disturbances. The proposed design technique is finally concluded in the light of a simulation example.