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一、引言近年来对于抗甲状腺药物诱发甲状腺肿瘤曾进行了很多的研究(Leathem,1958;Напалков,1960),但是关于肿瘤的形成过程还是停留于过去的解释上,认为是由于抗甲状腺药物抑制甲状腺素的综合后,使血流中甲状腺素含量降低,因而引起垂体的反馈作用,分泌大量促甲状腺激素,刺激甲状腺肥大增生,并引起代谢和遗传祖成上的改变所致(Rawson等,1957;Pitt-River等,1959)。至于甲状腺肿瘤演发时促甲状腺激素所起的具
I. INTRODUCTION There have been a lot of studies on anti-thyroid drug-induced thyroid tumors in recent years (Leathem, 1958; Напалков, 1960), but the process of tumor formation still rests on the past explanation, which is attributed to anti-thyroid drugs inhibiting thyroid After synthesis, blood levels of thyroxine decrease, causing the feedback effect of the pituitary gland, secrete a large number of thyroid stimulating hormone, stimulating hypertrophy of thyroid hypertrophy, and cause metabolic and genetic ancestral changes caused by (Rawson et al., 1957; Pitt-River et al., 1959). As thyroid tumors evolve thyroid-stimulating hormone from the set