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目的:探讨G3BP(Ras-GTPase-activiting protein SH3 domain binding protein)在结肠癌组织中的表达及其临床病理意义。方法:用免疫组织化学技术检测50例结肠癌组织中G3BP的表达,并分析其与患者临床病理指标的关系及其对预后的影响。结果:G3BP在结肠癌中阳性表达率为72%(36/50),G3BP的阳性表达率与肿瘤分化程度、淋巴结转移、病变浸润层次及TNM分期有关。而与年龄、性别、肿瘤大小无关(P>0.05)。G3BP高表达组患者的生存时间明显短于低表达组。结论:G3BP表达与结肠癌的侵袭和转移相关,可能是结肠癌的预后差的指标。
Objective: To investigate the expression of G3BP (Ras-GTPase-activating protein SH3 domain binding protein) in human colon cancer and its clinicopathological significance. Methods: The expression of G3BP in 50 cases of colon carcinoma was detected by immunohistochemistry. The relationship between the expression of G3BP and clinicopathological parameters and the prognosis were analyzed. Results: The positive expression rate of G3BP in colon cancer was 72% (36/50). The positive expression rate of G3BP was correlated with the degree of tumor differentiation, lymph node metastasis, the level of infiltrating lymph nodes and TNM staging. But not with age, sex, tumor size (P> 0.05). The survival time of G3BP high expression group was significantly shorter than that of low expression group. Conclusion: The expression of G3BP is correlated with the invasion and metastasis of colon cancer, which may be a marker of poor prognosis of colon cancer.