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目的探讨丹参川芎嗪注射液治疗慢性充血性心力衰竭患者的临床疗效。方法选取2012年10月至2014年11月沈阳市第十人民医院收治的180例慢性充血性心力衰竭患者作为研究对象,按随机数字表法将其分为观察组(80例)和对照组(100例)。对照组患者给予常规药物治疗,观察组患者在对照组采用丹参川芎嗪注射液进行治疗,比较两组患者治疗前后左心室射血分数(LVEF)、左心室每搏输出量(SV)、心指数(CI)、临床疗效及不良反应发生情况。结果治疗后,观察组患者的LVEF、SV、CI均明显高于对照组,差异均有统计学意义(均P<0.05);观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论在常规药物治疗基础上加用丹参川芎嗪注射液,可有效改善慢性充血性心力衰竭患者的心功能状况,增强其心肌收缩功能,且安全性较高。
Objective To investigate the clinical effect of ligustrazine injection on patients with chronic congestive heart failure. Methods A total of 180 patients with chronic congestive heart failure admitted to the Tenth People’s Hospital of Shenyang from October 2012 to November 2014 were selected and divided into observation group (n = 80) and control group (n = 100 cases). The patients in the control group were treated with conventional drugs. The patients in the observation group were treated with Ligustrazine and Ligustrazine in the control group. The left ventricular ejection fraction (LVEF), left ventricular stroke volume (SV), cardiac index (CI), clinical efficacy and adverse reactions. Results After treatment, the LVEF, SV and CI in the observation group were significantly higher than those in the control group (all P <0.05). The total effective rate in the observation group was significantly higher than that in the control group Significance (P <0.05). Conclusion Adding Salviae miltiorrhizae ligustrazine injection on the basis of routine drug therapy can effectively improve the cardiac function and improve the myocardial contractile function in patients with chronic congestive heart failure and its safety is high.