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目的探讨泌尿系结石所致疼痛的治疗方法。方法将泌尿系结石所致疼痛的病人160例随机分为4组:2%盐酸利多卡因注射液及丁溴东莨菪碱注射液组(治疗组)40例;盐酸哌替啶注射液组(对照组1)40例;黄体酮注射液组(对照组2)40例;阿托品注射液组(对照组3)40例,比较用药后疼痛缓解情况。结果治疗组、对照组1、对照组2和对照组3治疗30min时显效率分别为50.0%、52.5%、5.0%和7.5%,60min时显效率分别为90.0%、87.5%、15.0%和17.5%。30、60min时的显效率,治疗组与对照组1比较,差异无统计学意义(P>0.05);治疗组均高于对照组2及对照组3(P均<0.05)。不良反应以治疗组(87.5%)和对照组3(85.0%)的口干发生率较高,其他不良反应发生率均低于50.0%,经对症处理或观察均可缓解。结论联合应用2%盐酸利多卡因注射液及丁溴东莨菪碱注射液治疗泌尿系结石引起的疼痛具有良好的止痛效果。
Objective To investigate the treatment of urinary stones caused by pain. Methods A total of 160 patients with pain caused by urolithiasis were randomly divided into 4 groups: 40% of lidocaine hydrochloride injection and 2% of scopolamine bromide injection group (treatment group) 1) 40 cases; progesterone injection group (control group 2) 40 cases; atropine injection group (control group 3) 40 cases, compared the pain relief after treatment. Results The effective rates of treatment group, control group 1, control group 2 and control group 3 were 50.0%, 52.5%, 5.0% and 7.5%, respectively. The effective rates were 90.0%, 87.5%, 15.0% and 17.5 %. The effective rate at 30 and 60 min was not significantly different between the treatment group and the control group 1 (P> 0.05). The treatment group was higher than the control group 2 and the control group 3 (all P <0.05). Adverse reactions to the treatment group (87.5%) and control group 3 (85.0%) higher incidence of dry mouth, other adverse reactions were less than 50.0%, symptomatic treatment or observation can be alleviated. Conclusions The combination of 2% lidocaine hydrochloride injection and scopolamine bromide injection has a good analgesic effect in the treatment of urinary stones-induced pain.