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本实验观察了低体温动物缺氧性肺血管收缩反应(HPV)的变化,同时对低体温前后动脉血浆去甲肾上腺素(NE)、TXB_2、(TXA_2稳定代谢产物)和6-keto-PGF_(1(?))(PGI_2稳定代谢产物)、5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)的含量进行了测定。结果发现:低体温时HPV明显增强,由低温前34.7±5.8%上升至57.6±6.8%(P<0.05)。哌唑嗪可以抑制其反应,用药后HPV为23.5±11.9%。低体温及低体温缺氧均可增加血浆NE浓度,两者上升的水平相近。与常温动物不同,低体温时缺氧不增加血浆6-keto-PGFt_(1(?))含量。此外,低体温及低体温缺氧时,5-HT含量明显减少。提示:低体温时HPV增强可能主要与肺血管α肾上腺素能受体功能改变有关;PGI_2的调节作用减弱也可能起一定作用:5-HT不参与其中的反应。
In this study, we observed the changes of hypoxic pulmonary vasoconstriction (HPV) in hypothermia animals before and after hypothermia, and the effects of norepinephrine (NE), TXB2, (TXA2 stable metabolites) and 6-keto-PGF_ 1 (?)) (PGI-2 stable metabolites), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined. The results showed that: HPV at low body temperature increased significantly from 34.7 ± 5.8% before hypothermia to 57.6 ± 6.8% (P <0.05). Prazosin can inhibit the reaction, after taking HPV 23.5 ± 11.9%. Hypothermia and hypothermia hypoxia can increase the concentration of plasma NE, both rising levels similar. Unlike normal temperature animals, hypoxia at hypothermia did not increase the plasma 6-keto-PGFt_ (1 (?)) Content. In addition, hypothermia and hypothermia hypoxia, 5-HT content was significantly reduced. Tip: hypothermia HPV may be mainly related to changes in pulmonary vascular adrenergic receptor function; PGI_2 regulatory effect may also play a role in: 5-HT is not involved in the response.