固醇调节元件结合蛋白(SREBPs)是重要的核转录因子,其主要作用是通过激活胆固醇、脂肪酸和甘油三脂(TG)合成及摄取的相关基因,维持体内脂质代谢的平衡.近年来有研究表明,SREBPs与炎症关系紧密,一方面,SREBPs可以促进炎症的发生和发展,另一方面,炎症可以影响SREBPs的表达,造成脂质代谢紊乱.深入研究SREBPs与炎症的关系,有助于为炎症与脂质代谢紊乱所致相关疾病的防治提供新的方向. Steroid regulatory element binding proteins (SREBPs) are important nuclear transcription factors whose primary role is to maintain the balance of lipid metabolism in vivo by activating the genes involved in the synthesis and uptake of cholesterol, fatty acids and triglycerides (TG) Studies have shown that SREBPs and inflammation are closely related, on the one hand, SREBPs can promote the occurrence and development of inflammation, on the other hand, inflammation can affect the expression of SREBPs, resulting in lipid metabolism disorders.Depth research SREBPs and inflammation, contribute to Inflammation and lipid metabolism disorders related to the prevention and treatment of diseases provide a new direction.