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肿瘤学领域具有临床疗效的化疗药物相继问世;但在临床上这些药物取得的治疗效果欠佳。由于化疗药物的选择常常是根据临床用药经验和药物适合大多数患者的特点来判断,因而在肿瘤治疗过程中,相当比例的患者出现过给药错误的现象。随着对各种化疗药物药效和毒副作用在患者间差异机制的进一步了解,目前研究人员主要对个体化治疗策略进行探讨;该策略涉及患者的生理因素、遗传特性和环境因素以及决定临床治疗的传统肿瘤特征。本篇综述以肿瘤临床用药为例,总结了常用化疗药物毒副作用的遗传药理学及预测。
In the field of oncology clinical efficacy of chemotherapy drugs have come out; but the clinical treatment of these drugs to obtain poor results. As the choice of chemotherapeutic drugs is often based on the experience of clinical medication and the characteristics of the drug suitable for the majority of patients to judge, so in the course of cancer treatment, a significant proportion of patients had given medication errors. With the further understanding of the mechanism of differences among patients on the efficacy and side effects of various chemotherapeutic drugs, the current researchers mainly explore individualized treatment strategies that involve the physiological, genetic and environmental factors of the patients and determine the clinical treatment The traditional tumor characteristics. This review summarizes the clinical pharmacology and prognosis of commonly used chemotherapeutic drugs in the case of clinical oncology.