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利用氟脲嘧啶(5-Fu)和呋氟脲嘧啶(FT-207)与β-环糊精(β-CD)形成主—客包合物后~(19)F化学位移的变化研究了这些包合物的组成和稳定常数。5-Fu和FT-207均与β-CD形成1:1包合物,包合物的稳定常数在40℃分别为17.0±1.7mol~(-1)·L和9.0±0.1mol~(-1)·L。研究结果还表明,与β-CD形成包合物后,5-Fu和FT-207的~(19)F化学位移的变化有较明显的差异,提示了它们分子中的氟脲嘧啶环在β-CD疏水性内腔中的位置是不同的。
The chemical shifts of ~ (19) F after the formation of a host-guest inclusion complex were studied by using fluorouracil (5-Fu) and furfural (FT-207) Composition and stability constants of inclusion compounds. 5-Fu and FT-207 all formed 1: 1 inclusion complex with β-CD. The stability constants of inclusion complex were 17.0 ± 1.7 mol·L -1 and 9.0 ± 0.1 mol·L -1 at 40 ℃, 1) · L. The results also showed that the chemical shifts of ~ (19) F in 5-Fu and FT-207 were significantly different from those of β-CD, suggesting that the fluorouracil ring in their molecules is in beta -CD The location in the hydrophobic lumen is different.