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我院放射医学系于1980～1982年间,首先在国内建立了人血T、B淋巴细胞集落培养方法,并应用于淋巴细胞增殖动力学和辐射敏感性研究中,准确地反映出剂量效应关系。在实验血液学方面,该实验方法对造血干细胞和造血祖细胞的研究起着补充作用。在免疫学方面,不仅给研究淋巴细胞的增殖分化提供了手段,更主要的是为开展B淋巴细胞的研究找到了特异性的丝裂原,证明了LPS对人血B淋巴细胞具有明显的激活作用,纠正了以往认为LPS对人血B淋巴细胞无作用的观点。
In the Department of Radiological Medicine in our hospital from 1980 to 1982, we first established a method of colony culture of human blood T and B lymphocytes in our country, which was applied to lymphocyte proliferation kinetics and radiation sensitivity studies to accurately reflect the dose-effect relationship. In experimental hematology, this experimental method complements the study of hematopoietic stem cells and hematopoietic progenitor cells. In terms of immunology, it not only provides a means for studying the proliferation and differentiation of lymphocytes, but also finds a specific mitogen for the study of B lymphocytes, which proves that LPS has obvious activation on human blood B lymphocytes. The role of correcting the previous view that LPS has no effect on human blood B lymphocytes.