缺血性脑损伤无一例外可导致血脑屏障(blood brainbarrier,BBB)结构的完整性破坏并使其通透性增加,造成严重的神经功能损伤,国内外学者为此做了大量研究。脑缺血早期即出现细胞因子和黏附分子的表达,促发炎症级联反应,导致白细胞活化,这是BBB损伤的基础。除此之外,基质金属蛋白 Without exception, ischemic brain injury can cause the integrity destruction of the blood-brain barrier (BBB) ​​structure and increase its permeability, resulting in serious neurological damage. Therefore, scholars at home and abroad have done a lot of research. The early stage of cerebral ischemia, the expression of cytokines and adhesion molecules, promote inflammation cascade, leading to activation of white blood cells, which is the basis of BBB damage. In addition, matrix metalloproteinases