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目的建立琥珀酸美托洛尔缓释片(47.5mg)的体外溶出度测定方法,为体内药效评价提供可靠的方法。方法利用ZRS-8G型智能溶出试验仪,采用小杯浆法,以250ml水为溶出介质,转速50r.min-1,在(37±0.5)℃下做体外溶出度试验,间隔一定时间取样,用紫外分光光度法(UV),在274nm波长下测定药物吸收度,从而计算出其溶出度。结果琥珀酸美托洛尔缓释片在24h的溶出百分率为93.88%。结论该方法准确、快速、简便易行,适用于琥珀酸美托洛尔的溶出度测定。
Objective To establish a method for in vitro dissolution determination of metoprolol succinate sustained-release tablets (47.5 mg), which can provide a reliable method for evaluating the efficacy of metoprolol succinate in vivo. Methods The ZRS-8G intelligent dissolution tester was used. The dissolution rate was 50r.min-1 with 250ml of water as the dissolution medium and the dissolution rate was measured at (37 ± 0.5) The degree of dissolution of the drug was measured by UV spectrophotometry (UV) at a wavelength of 274 nm to calculate its dissolution rate. Results Metoprolol succinate sustained-release tablets dissolved in 24h percentage of 93.88%. Conclusion The method is accurate, rapid, simple and easy to perform and is suitable for the determination of dissolution of metoprolol succinate.