论文部分内容阅读
为了探讨进展期贲门癌患者脾脏的免疫状态，分别检测了７０例患者的外周血、脾静脉血与脾脏的ＮＫ细胞活性及Ｔ－淋巴细胞亚群。结果显示：（１）与正常人外周血淋巴细胞（ＰＢＬ）相比，进展期贲门癌患者的ＰＢＬ，脾静脉血淋巴细胞（ＳＶＬ）及脾细胞（ＳＣ）的ＮＫ细胞活性、ＣＤ３＋、ＣＤ４＋细胞降低，ＣＤ８＋细胞增多，致ＣＤ４＋／ＣＤ８＋细胞比值明显下降；（２）从进展期贲门癌患者ＰＢＬ、ＳＶＬ与ＳＣ三者之间比较结果可见，后二者的ＮＫ细胞活性、ＣＤ４＋／ＣＤ８＋细胞比值均明显低于ＰＢＬ。作者认为，进展期贲门癌能削弱患者的整体免疫功能；随着肿瘤的进展，脾脏不但未能起正性免疫作用。且逐步转向负性免疫状态。
To investigate the immune status of spleen in patients with advanced cardiac cancer, NK cell activity and T-lymphocyte subsets in peripheral blood, spleen venous blood and spleen of 70 patients were examined. The results showed: (1) Compared with normal human peripheral blood lymphocytes (PBL), NK cell activity, CD3+, CD4+ cells in advanced blood vessel lymphocytes (PBL), splenic venous lymphocytes (SVL) and spleen cells (SC) Decreased, CD8+ cells increased, resulting in a significant decrease in the ratio of CD4+/CD8+ cells; (2) The results of the comparison between the PBL, SVL, and SC of advanced cardiac cancer patients showed that the latter two had NK cell activity and CD4+/CD8+ cell ratio. Both are significantly lower than PBL. The authors believe that advanced cardia cancer can weaken the patient’s overall immune function; with the progress of the tumor, the spleen not only fails to play a positive immune function. And gradually turned to negative immune status.