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目的分析食管癌组织中趋化因子受体(CXCR4)和血管内皮生长因子(VEGF-C)的表达意义。方法抽取本院1996年1月至2015年1月期间就诊并经病理检查确诊为食管癌患者72例作为研究组,选取同期正常食管组织患者60例作为对照组,采取免疫组织化学方法测定2组CXCR4、VEGF-C表达情况。结果 CXCR4在食管癌组织、正常组织中阳性表达率分别为62.50%、0.00%,VEGF-C在食管癌组织、正常组织中阳性表达率分别为61.11%、6.67%,组间比较差异有统计学意义(P<0.05);CXCR 4在食管癌组织中的表达与TN M分期、病理类型、组织分化程度、淋巴结转移及肿瘤浸润深度等有相关性(P<0.05);VEGF-C在食管癌组织中的表达与TNM分期、淋巴结转移、肿瘤浸润深度等比较有相关性(P<0.05);CXCR4和VEGF-C的关系在食管癌中的表达呈正相关(P<0.05)。结论在食管癌组织中CXCR4、VEGF-C呈高表达,且与淋巴结转移有相关性,通过采取CXCR4、VEGF-C联合检测的方式,不仅有利于食管癌侵袭、淋巴结转移的判断,同时有利于其预后的判断,具有重要的临床价值。
Objective To analyze the expression of chemokine receptor (CXCR4) and vascular endothelial growth factor (VEGF-C) in esophageal cancer tissues. Methods Seventy-two patients diagnosed as esophageal cancer from January 1996 to January 2015 in our hospital were selected as the study group. Sixty normal esophageal tissue patients were selected as the control group during the period from January 1996 to January 2015, and two groups were determined by immunohistochemistry CXCR4, VEGF-C expression. Results The positive rates of CXCR4 in esophageal cancer tissues and normal tissues were 62.50% and 0.00%, respectively. The positive rates of VEGF-C in esophageal cancer tissues and normal tissues were 61.11% and 6.67%, respectively. The differences between the two groups were statistically significant (P <0.05). The expression of CXCR4 in esophageal cancer was correlated with TNM staging, histological type, histological differentiation, lymph node metastasis and depth of tumor invasion (P <0.05) There was a significant correlation between the expression of CXCR4 and VEGF-C in TNM stage, lymph node metastasis and tumor infiltration depth (P <0.05). The correlation between the expression of CXCR4 and VEGF-C in esophageal cancer was statistically significant (P <0.05). Conclusion CXCR4 and VEGF-C are highly expressed in esophageal cancer tissues and correlate with lymph node metastasis. The combined detection of CXCR4 and VEGF-C is not only beneficial to the detection of esophageal cancer invasion and lymph node metastasis, but also beneficial to The prognosis of the judgment, has important clinical value.