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长期以来怀疑感染是获得性纯红细胞再生障碍性贫血(再障危象)及幼儿急疹的病因。1981年首次报道再障危象与小DNA病毒(Parvovirus)B_(19)感染有关。1983年报道该病毒与幼儿急疹的关系。1984年,美国俄亥俄州东北部地区发生了再障危象及幼儿急疹的同时暴发流行。作者通过配对分组,进行血清学生物学方面的研究,发现小DNA病毒B_(19)和此二种病有关。用ELISA方法检测了26例患有再障危象病人的血清,其中24例急性期或恢复期血清有特异性的抗小DNA病毒B_(19)的IgM抗体,而对照组33人血清抗B_(19)-IgM均阴性。病例中13个血清中有B_(19)DNA。
Suspected infection for a long time is the cause of acquired pure red cell aplasia (aplastic anemia) and children with acute rash. The first reported in 1981, azoospermia and small DNA virus (Parvovirus) B_ (19) infection. 1983 reported the virus and the relationship between children with acute rash. In 1984, the northeastern Ohio region of the United States occurred in a crisis of aplastic barrier and young children at the same time the outbreak of rash. By pairwise grouping, the authors carried out serological studies, and found that small DNA virus B_ (19) is associated with both diseases. Serum samples from 26 patients with aplastic anemia were detected by ELISA. Twenty-four of the 24 patients with acute or convalescent sera had IgM antibody against B DNA micro-DNA (19), while 33 of the control group had anti-B_ (19) -IgM are negative. 13 cases of serum B 19 DNA.