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已经发现转化生长因子α（ＴＧＦα）及其受体表皮生长因子受体（ＥＧＦＲ）在多种人类恶性肿瘤中有表达．并与这些肿瘤病人的预后有密切关系。本实验观察了体外培养人肝癌细胞株，荷人肝癌裸鼠模型，以及肝癌病人的肿瘤标本中ＴＧＦα和ＥＧＦＲ的表达及其与肝癌生长的关系。结果显示两种裸鼠模型中．ＥＧＦＲ表达强的肿瘤生长快；培养肝癌细胞在ＴＧＦα刺激下ＥＧＦＲ表达明显增强，同时细胞分裂指数也明显增加；在一组人肝癌标本中，ＴＧＦα和ＥＧＦＲ在瘤内表达阳性组的平均瘤径明显大于阴性组。此项研究证实ＴＧＦα和ＥＧＦＲ的表达能够促进肝癌细胞的生长从而影响肝癌病人的预后。
It has been found that transforming growth factor alpha (TGF alpha) and its receptor epidermal growth factor receptor (EGFR) are expressed in a variety of human malignancies. And is closely related to the prognosis of these tumor patients. In this experiment, we observed the expression of TGFα and EGFR in human hepatocellular carcinoma cell lines, human hepatocellular carcinoma nude mice models, and tumor specimens of liver cancer patients and their relationship with the growth of hepatocellular carcinoma. The results are shown in two nude mice models. The tumors with strong EGFR expression grow rapidly; the expression of EGFR in cultured hepatoma cells stimulated by TGFα is significantly enhanced and the cell division index is also significantly increased; in a group of human liver cancer specimens, the mean tumor diameters of TGFα and EGFR positive expression groups in tumors are significantly different. Greater than negative group. This study confirmed that the expression of TGFα and EGFR can promote the growth of hepatoma cells and thus affect the prognosis of patients with liver cancer.