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目的 :探讨治疗前后不同时期胃肠道恶性肿瘤患者血清CEA水平的变化规律及临床意义。方法 :采用CEA单克隆抗体酶联免疫检测试剂盒 ,检测患者血清CEA水平 ,用统计学方法对检测结果进行比较分析。结果 :胃肠道恶性肿瘤患者手术前CEA水平显著高于健康人(P<0.005) ,手术后CEA普遍降低至较低水平。当患者再进行化疗时 ,化疗结束后60天内81.8%(18/22)的患者血清CEA有升高现象 ;61天～180天再次复查时 ,其中13例患者CEA水平又降至化疗前的水平。结论 :手术治疗可降低胃肠道恶性肿瘤患者的血清CEA水平 ;化学药物治疗可使患者出现短暂的(60天内)、可恢复的血清CEA升高过程 ,在此期间内CEA值尚不能作为肿瘤复发或转移的指征。动态分析患者CEA水平对肿瘤诊断和疗效评价有重要意义 ,化疗后患者CEA水平升高的机制待进一步研究。
Objective: To investigate the changes and clinical significance of serum CEA levels in patients with gastrointestinal cancer at different periods before and after treatment. Methods: CEA monoclonal antibody ELISA kit was used to detect the level of serum CEA in patients with statistical methods to compare the test results. Results: The preoperative CEA level in patients with gastrointestinal cancer was significantly higher than that in healthy people (P <0.005). CEA generally decreased to a lower level after operation. When the patient underwent further chemotherapy, 81.8% (18/22) of the patients within 60 days after the end of chemotherapy had elevated serum CEA; in 61 days to 180 days of re-examination, the CEA level in 13 of them dropped to the level before chemotherapy . CONCLUSIONS: Surgical treatment can reduce serum CEA levels in patients with gastrointestinal malignancies. Chemotherapy can result in transient (within 60 days) recanalization of elevated serum CEA levels during which time CEA values are not yet available as tumors Indications of recurrence or metastasis. The dynamic analysis of CEA levels in patients with tumor diagnosis and evaluation of efficacy is important, the mechanism of CEA levels in patients after chemotherapy to be further studied.