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目的：探讨淋巴瘤、多发性骨髓瘤患者有无血栓前状态，判断病情，以其指导治疗。方法：采用放射免疫法、发色底物法等对４０例淋巴瘤、２４例多发性骨髓瘤的血小板表面α－颗粒膜蛋白、凝血酶原、凝血酶、血管性假血友病因子及抗凝血酶Ⅲ进行了测定。结果：前三项指标淋巴瘤组分别为４２．５％、３０％和４５％，多发性骨髓瘤组分别为６２．５％、２０．５％和５８．３％患者较正常升高。少数晚期淋巴瘤抗凝血酶Ⅲ含量下降。晚期淋巴瘤较早期易发生血栓前状态。结论：淋巴浆细胞系统恶性肿瘤常伴血栓前状态，其程度与病期相关
Objective: To investigate the prethrombotic state of patients with lymphoma and multiple myeloma, determine the condition, and guide treatment. METHODS: Radioimmunoassay and chromogenic substrate method were used on platelet surface alpha-granule membrane protein, prothrombin, thrombin, von Willebrand factor, and anti-tumor activity in 40 cases of lymphoma and 24 cases of multiple myeloma. Thrombin III was measured. RESULTS: The first three indicators were 42.5%, 30%, and 45% in the lymphoma group, and 62.5%, 20.5%, and 58.3% in the multiple myeloma group were higher than normal. A small number of advanced lymphomas have decreased levels of antithrombin III. Late lymphoma is prone to prethrombotic state earlier. CONCLUSIONS: Lymphocytic cell system malignancies are often associated with prethrombotic conditions, the extent of which is related to the stage of the disease.