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目的:观察健脑通络方(JNTL)对血管性痴呆大鼠大脑神经递质的影响,探讨其治疗血管性痴呆的作用机理。方法:以颈内动脉暂时夹闭加颈外动脉注射栓子方法造成多发性脑梗塞,加注山莨菪碱,以记忆力检测模型,测量各组大鼠脑内去甲肾上腺素、乙酰胆碱、多巴胺、5-羟色胺的含量。结果:给药组大脑皮层的各种递质含量明显增加。结论:JNTL可提高血管性痴呆动物大脑皮层的神经递质含量,具有一定的健脑益智的实验室基础。
OBJECTIVE: To observe the effects of JNTL on cerebral neurotransmitters in vascular dementia rats and to explore its mechanism of action in treating vascular dementia. METHODS: Multiple cerebral infarctions were induced by transient occlusion of the internal carotid artery and injection of emboli into the external carotid artery. Anisodamine was given by anesthesia. A memory model was used to measure the levels of norepinephrine, acetylcholine, and dopamine in the brains of rats in each group. Serotonin content. Results: The content of various transmitters in the cerebral cortex increased significantly in the administration group. Conclusion: JNTL can increase the content of neurotransmitters in cerebral cortex of vascular dementia animal, and has a certain laboratory basis for brain puzzle.