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目的观察刺五加皂甙对慢性脑缺血大鼠认知功能的干预效应及其可能机制。方法采用四血管结扎的全脑缺血模型,制模成功后大鼠随机分为脑缺血组、刺五加皂甙组,同时设立假手术组,刺五加皂甙组大鼠分别按剂量25 mg/kg、50 mg/kg、100 mg/kg刺五加皂甙腹腔注射,观察大鼠认知功能变化、免疫组化法分析海马血管内皮生长因子(VEGF)表达、透射电镜下海马超微结构的变化。结果与假手术组比较,脑缺血组大鼠的学习记忆能力明显受损、海马VEGF蛋白表达明显增高(P<0.01);与脑缺血组比较,刺五加皂甙组大鼠认知功能明显改善、海马VEGF表达明显降低(P<0.05)。结论刺五加皂甙可通过抑制VEGF表达显著改善缺血性脑损伤模型大鼠认知功能,呈剂量依赖性。
Objective To observe the intervention effect of acanthopanax senticosus on cognitive function in chronic cerebral ischemia rats and its possible mechanism. Methods The model of global cerebral ischemia with four-vessel ligation was established. After successful modeling, the rats were randomly divided into cerebral ischemia group and acanthopanax senticosus group. At the same time, rats in sham group and acanthopanax senticosus group were treated with 25 mg kg / kg, 50 mg / kg, 100 mg / kg acanthopanax senticosus were injected intraperitoneally to observe the changes of cognitive function in hippocampus. Immunohistochemistry was used to analyze the expression of vascular endothelial growth factor (VEGF) in hippocampus and ultrastructure of hippocampus under transmission electron microscope Variety. Results Compared with the sham operation group, the learning and memory abilities of the rats with cerebral ischemia were significantly impaired and the expression of VEGF protein in the hippocampus was significantly increased (P <0.01). Compared with the cerebral ischemia group, the cognitive function of acanthopanax senticosus groups Significantly improved, the expression of VEGF in hippocampus decreased significantly (P <0.05). Conclusion Acanthopanax senticosus can significantly improve the cognitive function of rats with ischemic brain injury by inhibiting VEGF expression in a dose-dependent manner.