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目的：探讨血清免疫球蛋白及补体检测应用于肾病综合征诊断和治疗的临床价值。方法采用免疫比浊法检测肾病综合征患者110例（A组）和健康体检者60例（B组）血清免疫球蛋白（IgG、IgA和IgM ）以及补体（C3和C4），分析其用于肾病综合征诊断的临床价值。结果 A组患者的IgG和IgA水平低于B组[（4.84±2.03） g／L vs ．（13.41±1.89） g／L和（1.75±0.73） g／L vs ．（2.55±0.62）g／L]，IgM水平高于B组[（2.93±0.49）g／L vs ．（1.53±0.15）g／L]（P＜0．05）。A组C3水平低于B组[（0.97±0.36） g／L vs ．（1.28±0.37） g／L]（P＜0．05）；两组C4水平无统计学差异[（0.28±0.05） g／L vs ．（0.63±0.06） g／L]（P＞0．05）。结论血清免疫球蛋白、体检测对于肾病综合征的诊断以及治疗能够起到积极的指导作用。“,”Objective To study the application value of detecting serum immunoglobulin and complement in the diagnosis of nephrotic syndrome .Methods Using immune turbidimetric method , serum levels of immunoglobulin(IgG ,IgA and IgM ) and complement(C3 and C4) were detected in 110 patients with nephrotic syndrome (group A ) and healthy people received physical examination (group B) .Application value of the detection in the diagnosis of nephrotic syndrome was analyzed . Results Serum levels of IgG and IgA were significantly lower in group A than those in group B [(4.84±2.03)g/Lvs.(13.41±1.89)g/Land(1.75±0.73)g/Lvs.(2.55±0.62)g/L](P<0.05),while serum IgM was higher in group A than that in group B[(2.93 ± 0.49) g/L vs .(1.53 ± 0.15) g/L] (P<0 .05) .Serum level of C3 was lower in group A than that in group B[(0.97 ± 0.36) g/L vs . (1.28 ± 0.37) g/L](P0 .05) .Conclusion The detections of serum immunoglobulin and complement may play a positive guiding role in the diagnosis and treatment of nephrotic syndrome .