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目的：阐明多胺对妇科肿瘤的诊断及治疗效果判断的意义。方法：本文用固相萃取及高效波相色谱测定法检测并比较了34例妇科恶性肿瘤（恶性组）、35例良性肿瘤患者（良性组）及37例健康女性问4照组）的尿多胺值，且短期随访了16例卵巢恶性肿瘤患者治疗（根治性手术或细胞灭减术及一次化疗）前、后尿中多胺值的变化。结果：恶性组（含复发癌4例）多胺值显著高于良性组及对照组;同样，卵巢恶性肿瘤患者的测定值亦显著高于卵巢良性病变及健康对照。16例卵巢恶性肿瘤患者经有效治疗后尿多胺值明显降低。结论：提示多胺不能作为某一特定肿瘤的特异性诊断标准，但对判断肿瘤的良、恶性以及治疗疗效和预测恶性肿瘤复发有一定意义。
Objective: To elucidate the significance of polyamines in the diagnosis of gynecological tumors and the judgment of therapeutic effect. Methods: The urinary excretion of 34 cases of gynecologic malignancy (malignant group), 35 cases of benign tumor (benign group) and 37 cases of healthy women asked 4 groups were detected and compared by solid phase extraction and high performance wave chromatography. Amine value, and short-term follow-up of 16 cases of ovarian cancer patients (curative surgery or cytoreductive surgery and a chemotherapy) before and after the change in urinary polyamine values. RESULTS: The polyamine values of the malignant group (including 4 cases with recurrent cancer) were significantly higher than those of the benign group and the control group. Similarly, the measured values of the ovarian cancer patients were also significantly higher than those of benign ovarian lesions and healthy controls. The urinary polyamine value was significantly reduced in 16 patients with malignant ovarian tumors after effective treatment. Conclusion: It is suggested that polyamine can not be used as a specific diagnostic criteria for a specific tumor, but it has certain significance for judging the benign and malignant tumors as well as the therapeutic efficacy and predicting the recurrence of malignant tumors.