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山东省医科院曹守维等在7例HBsAg携带者的肝细胞内查见巨大线粒体内结晶包涵体,并发现了包涵体的“超形态学单位”和“形态学单位”。前者直径约为4个埃,每5个组成一个空心的五边形花环状结构;该结构在电镜下为一个直径约3.8nm的“形态学单位”。每6个形态学单位组成一个带核心颗粒的五边形平盘样结构,直径约40nm。经国际联机检索证实,此为国内外首次发现,为肝炎的病源学和发病学研究开辟了新领域。
Cao Shouwei et al. of Shandong Academy of Medical Sciences investigated giant mitochondrial crystal inclusions in the liver cells of seven HBsAg carriers and found “hypermorphic units” and “morphological units” of inclusion bodies. The former has a diameter of about 4 angstroms, and each five forms a hollow pentagonal flower ring structure; the structure under the electron microscope is a “morphological unit” with a diameter of about 3.8 nm. Each six morphological units consist of a pentagonal flat disk-like structure with core particles, approximately 40 nm in diameter. Confirmed by an international online search, this is the first time that it has been discovered at home and abroad, opening up new fields for the study of the etiology and pathogenesis of hepatitis.