本文对氟哌酸、氟啶酸、丙氟哌酸、甲氟哌酸、氨氟哌酸和多氟哌酸等第三代吡啶酮酸类抗菌药的体内外抗菌作用和药代动力学作了概括性论述。对前四种抗茵药还叙述了临床适应症、疗效和毒副反应。临床应用表明这四种药对各科急性和慢性感染疗效显著,有效率为80～86%,毒副反应少。 The antibacterial activities and pharmacokinetics of the third generation pyridone acid antibacterials such as norfloxacin, fubicid, propoxyphene, mefloxacin, amoxicillin and polyfloxacin in vitro and in vivo The general discussion. The first four anti-inflammatory drugs also described the clinical indications, efficacy and toxicity. Clinical application shows that these four kinds of drugs have obvious curative effect on acute and chronic infections in all subjects, with an effective rate of 80-86% and few toxic and side effects.