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为探讨氧自由基与老年期痴呆发生发展的关系，分别测定了２７例阿尔采默型老年期痴呆（ＳＤＡＴ），２７例多发梗塞性痴呆（ＭＩＤ）患者和３７例同龄的健康老年人血清中超氧化物歧化酶（ＳＯＤ）及其同功酶活性和ＬＰＯ含量．结果显示：ＳＤＡＴ和ＭＩＤ患者的Ｔ－ＳＯＤ、ＣｕＺｎ－ＳＯＤ活性和ＬＰＯ含量均显著高于同龄的对照组，其中ＣｕＺｎ－ＳＯＤ的异常阳性率最高，达５９．３％；Ｔ－ＳＯＤ、ＣｕＺｎ－ＳＯＤ在不同病程的三组间有显著差异．提示ＳＤＡＴ和ＭＩＤ患者体内氧化与抗氧化之间的平衡紊乱，脂质过氧化反应增强，机体抗氧化酶系统的保护功能减弱，对探讨ＳＤＡＴ和ＭＩＤ的病因和发病机理具有一定的意义
In order to explore the relationship between oxygen free radicals and the development of senile dementia, 27 patients with Alzheimer’s dementia (SDAT), 27 patients with multi-infarct dementia (MID) and 37 healthy controls Oxidative dismutase (SOD) and its isoenzyme activity and LPO content. The results showed that the T-SOD, CuZn-SOD activity and LPO content in SDAT and MID patients were significantly higher than those in the same age group. The positive rate of CuZn-SOD was the highest (59.3% SOD in different course of the three groups were significantly different. It is suggested that the imbalance of oxidation and anti-oxidation, the increase of lipid peroxidation and the protective function of the body’s antioxidant enzyme system in SDAT and MID patients are of great significance in exploring the etiology and pathogenesis of SDAT and MID