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目的:观察抗结核化疗药物对乙肝表面抗原阳性的结核性胸膜炎患者肝功能的影响。方法:采用2SHRZ/6HRE化疗方案对41例结核性胸膜炎HBsAg阳性患者进行治疗,疗程结束后观察患者肝功能情况。结果:HBsAg阳性结核性胸膜炎其肝功能异常发生率7.32%。较文献报道为低。结论:HBsAg阳性结核性胸膜炎患者在应用抗结核治疗过程中,只要严格按规定用量,常规给药,较为安全,但应极时复查肝功,以策安全。
Objective: To observe the effect of anti-tuberculosis chemotherapeutics on liver function in patients with tuberculous pleurisy who are positive for hepatitis B surface antigen. Methods: 41 cases of tuberculous pleurisy HBsAg positive patients were treated by 2SHRZ / 6HRE chemotherapy. The liver function of the patients was observed after treatment. Results: The incidence of abnormal liver function in HBsAg positive tuberculous pleurisy was 7.32%. Lower than reported in the literature. Conclusion: HBsAg positive tuberculous pleurisy patients in the application of anti-TB treatment, as long as the required amount strictly in accordance with the regulations, the routine administration, more safe, but should be extremely review of liver function, in order to make safety.