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采用对羟基苯甲酸甲酯、4-羧基苯并-15-冠醚-5等物质为原料制备了具有自组装功能的两亲性冠醚化合物2-羟甲基-[1,4,7,10,13-苯并15冠5]-3,4,5-三[4-(10-十二烷基-1-羰基)苄氧基]苯甲酸,采用FT-IR,1H NMR,MS,DSC以及POM等方法对其化学结构和结晶性能进行表征.利用紫外光接枝法将制得的冠醚化合物接枝到聚碳酸酯核孔膜表面构筑了离子通道膜,接枝量为606μg/cm2.采用ATR-FTIR和XPS分析离子通道膜的表面元素组成和化学键合情况,SEM和AFM用于检测离子通道膜表面和断面的微观结构.结果表明,这种两亲性冠醚化合物在核孔膜的表面自行组装形成了由大量柱状结构组成的致密皮层.利用实验室自制的膜运输装置对离子传输性能进行了测评,离子通道膜平均离子通过效率PFM=20.62×10-6 cm/s,对比膜与其的分离系数αFM/NFM=5.96,数据证实合成的两亲性冠醚化合物能特异性地识别和运输Na+,由其制得的离子通道膜是一种Na+识别型离子通道膜.
The amphiphilic crown ether compounds 2-hydroxymethyl- [1,4,7-diazabicyclo (4-hydroxymethyl) 10,13-benzo-15-crown-5] -3,4,5-tris [4- (10-dodecyl- 1 -carbonyl) benzyloxy] benzoic acid using FT-IR, DSC and POM were used to characterize its chemical structure and crystallinity.Using UV grafting method, the obtained crown ether compound was grafted onto the surface of polycarbonate core membrane to construct an ion channel membrane with grafting amount of 606 μg / cm2.The surface elemental composition and chemical bonding of ion channel membrane were analyzed by ATR-FTIR and XPS.The SEM and AFM were used to detect the microstructure of ion channel membrane surface and cross-section.The results showed that the amphiphilic crown ether compound in the nucleus The surface of the membrane was self-assembled to form a dense cortex composed of a large number of columnar structures. The ion transport properties of the membrane were measured by a membrane transporter manufactured by the laboratory. The average ion passage efficiency of the ion channel membrane was 20.62 × 10-6 cm / s , The separation coefficient αFM / NFM = 5.96 was compared with the membrane, the data confirmed that the synthetic amphiphilic crown ether compound can specifically recognize and transport Na + Have a membrane ion channel identification Na + ion channel membrane.