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目的探讨系统性红斑狼疮(SLE)患者血清巨噬细胞移动抑制因子(MIF)、C反应蛋白(CRP)水平变化与患者肾功能变化的影响。方法酶联免疫吸附法(ELISA)检测35例SLE患者MIF水平,同时检测β2微球蛋白(β2-MG)、尿微量白蛋白(m-Alb)、血清尿素氮(BUN)、血清肌酐(SCr)水平,健康体检者(15名)为对照,比较分析肾功能正常组与肾功能异常组、SLE活动组与非活动组间相关指标变化。结果 SLE肾功能异常组MIF、尿m-Alb及SCr水平显著高于SLE肾功能正常组及健康对照组,SLE各组CRP水平无差异,但均高于健康对照组。SLE活动组MIF和CRP水平均高于SLE非活动组。SLE肾功能正常组内MIF与CRP呈正相关,SLE肾功能异常组内MIF与CRP、m-Alb、β2-MG均呈正相关;m-Alb与β2-MG呈正相关,BUN与SCr呈正相关。结论 MIF水平变化与患者血清CRP及肾功能恶化程度一致,其参与SLE患者肾损害过程,MIF的监测对判断SLE肾损害程度、指导临床治疗有重要价值。
Objective To investigate the changes of serum macrophage migration inhibitory factor (MIF) and C-reactive protein (CRP) levels in patients with systemic lupus erythematosus (SLE) and the changes of renal function. Methods The levels of MIF in 35 SLE patients were detected by enzyme-linked immunosorbent assay (ELISA). The levels of β2-MG, m-Alb, BUN and SCr ), Healthy subjects (15) as control, comparative analysis of normal renal function group and renal dysfunction group, SLE activity group and inactive group related indicators. Results The levels of MIF, urinary m-Alb and SCr in SLE renal dysfunction group were significantly higher than those in normal renal function group and healthy control group. The levels of CRP in SLE groups were all higher than those in healthy control group. SLE activity group MIF and CRP levels were higher than SLE inactive group. There was a positive correlation between MIF and CRP in normal renal function SLE group, positive correlation between MIF and CRP, m-Alb and β2-MG in SLE renal dysfunction group, positive correlation between m-Alb and β2-MG, and positive correlation between BUN and SCr. Conclusion The changes of MIF levels are consistent with the serum levels of CRP and renal function in patients with SLE. It is involved in the process of renal damage and the monitoring of MIF plays an important role in judging the extent of renal damage and guiding the clinical treatment.