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目的探讨氢氧化铝致猫运动区癫痫模型的制作方法及病理、超微结构变化。方法在猫的左侧大脑乙状前回注入氢氧化铝乳剂或生理盐水50μl。术后观察猫的行为学变化,皮层脑电图变化,20周后取材观察病理及超微结构变化。结果实验组于术后11~14周时发现临床癫痫发作;实验组于8周时检测到皮层棘波放电,12周时放电次数最明显,持续到20周仍有棘波放电,且趋于稳定;实验组HE染色及透射电镜观察显示相应病理改变。结论成功制成氢氧化铝癫痫模型,其病理改变是导致大脑皮层棘波放电和癫痫发作的结构基础。
Objective To investigate the method of making aluminum hydroxide-induced epilepsy in cat’s motor area and its pathological and ultrastructural changes. Methods In the cat’s left brain before the retrograde infusion of aluminum hydroxide emulsion or saline 50μl. Postoperative observation of cat behavior changes, cortical EEG changes, 20 weeks after the observation of pathological and ultrastructural changes. Results In the experimental group, clinical seizures were found at 11 to 14 weeks after operation. In the experimental group, the cortical discharge was detected at 8 weeks, and the discharge was most obvious at 12 weeks. Spike discharge continued to occur at 20 weeks, Stable; experimental group HE staining and transmission electron microscopy showed the corresponding pathological changes. Conclusion The aluminum hydroxide epilepsy model was successfully established, and its pathological changes were the structural basis of spike wave discharge and epileptic seizures in the cerebral cortex.