近年来,随着对血小板的生理生化及其功能认识的不断深化以及造血细胞体外培养技术的发展,人们越来越重视对血小板生成细胞——巨核细胞的研究。1975年Metcalf首次建立了小鼠巨核细胞集落形成细胞(CFUMK)体外培养方法,揭开了探讨CFU-MK的生长特点、调节机制以及与其它各种造血细胞相互间关系的序幕。随着这一工作的深入,有关人类CFU-MK体外培养的研究也取得了 In recent years, with the deepening understanding of the physiology and biochemistry of platelets and their function, as well as the development of hematopoietic cell culture technology in vitro, more and more attention has been paid to the study of platelet-producing cells, megakaryocytes. In 1975, Metcalf firstly established the in vitro culture method of mouse megakaryocyte colony forming cells (CFUMK), and explored the characteristics of CFU-MK growth, regulatory mechanism and the relationship with other kinds of hematopoietic cells. As this work progresses, a study on human CFU-MK in vitro culture has also been made