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目的探讨一种敏感的肺癌辅助诊断方法。方法采用乳胶凝集法对 144例良、恶性肺部疾病患者和 2 8例健康人血清肺肿瘤抗原 (LTA)进行检测。结果肺癌组阳性率 78.3 % ,对照组阳性率 7.6 % ,差异有非常显著意义 (P <0 .0 1) ;其中非小细胞肺癌阳性率 88.2 % ,小细胞肺癌阳性率7.7% ,差异亦有非常显著意义 (P <0 .0 1)。肺癌组中包括 2例原位癌患者 ,血清LTA检测均呈阳性 ,说明血清LTA检测有助于早期肺癌的发现。结论血清LTA检测是一种快速、简便、敏感的肺癌 (尤其是非小细胞肺癌 )辅助诊断方法。
Objective To explore a sensitive method for the diagnosis of lung cancer. Methods The serum lung tumor antigen (LTA) was detected in 144 patients with benign and malignant lung diseases and 28 healthy persons using latex agglutination. Results The positive rate was 78.3% in the lung cancer group and 7.6% in the control group (P < 0.01). The positive rate of non-small cell lung cancer was 88.2%, and the positive rate of small cell lung cancer was 7.7%. There were also differences. Very significant (P < 0.01). In the lung cancer group, two patients with carcinoma in situ were included. The serum LTA test was positive, indicating that serum LTA detection is helpful for the early detection of lung cancer. Conclusion Serum LTA detection is a rapid, simple and sensitive method for the diagnosis of lung cancer (especially non-small cell lung cancer).