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目的 :观察灯笼草的镇痛作用。方法 :采用扭体法、电刺激鼠尾 嘶叫法、钾离子透入法和辐射热 缩腿法等行为学指标以及丘脑束旁核神经元对伤害性刺激的放电反应的电生理指标。结果 :灯笼草能剂量依赖地提高大鼠电刺激鼠尾 嘶叫法的痛阈 ,剂量依赖地抑制醋酸引起的小鼠扭体反应 ,对炎症性痛敏及神经源性痛敏灯笼草也有镇痛作用 ,灯笼草还能明显抑制丘脑束旁核神经元对伤害性刺激的放电反应。纳洛酮能翻转灯笼草的镇痛作用 ,反复给予灯笼草能产生耐受 ,但与吗啡镇痛之间不存在交叉耐受。结论 :灯笼草具有镇痛作用 ,其镇痛作用可能涉及中枢阿片受体。
Objective: To observe the analgesic effect of lantern grass. Methods : Electrophysiological parameters such as writhing, electrical stimulation of rat tail cercariae, potassium ion penetration method and radiant heat contraction leg were used as well as the electrophysiological parameters of the thalamus parabrachial nucleus neurons in response to noxious stimulation. RESULTS: Pterocarpus irradius could dose-dependently increase the rat’s irritative threshold for electrical stimulation of rat tail tweezer, dose-dependently inhibited acetic acid-induced writhing in mice, and had an effect on inflammatory hyperalgesia and neuropathic pain. The painful effect of lantern grass can also significantly inhibit the thalamic paranuclear nucleus neurons’ discharge response to noxious stimulation. Naloxone can reverse the analgesic effect of lantern grass and repeatedly give P. arundinacea tolerant, but there is no cross-tolerance with morphine analgesia. Conclusion : Pterocarpus has analgesic effect and its analgesic effect may involve central opioid receptors.