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脓毒症和脓毒性休克合并的肾脏组织缺血/再灌注损伤已成为重症患者的常见并发症,积极恢复肾组织血流,减轻或防止再灌注损伤的发生仍是目前研究的方向。其发病机制包括细胞坏死与凋亡及钙离子超载、氧自由基增多~([1])、多种细胞因子及黏附分子等炎性递质的表达增加。寻找有效的多靶点药物防治肾组织缺血/再灌注损伤是目前基础和临床的研究热点。研究已表明,他汀类药物不仅具有显著的降脂作用,还可
Renal ischemia / reperfusion injury combined with sepsis and septic shock has become a common complication in critically ill patients. It is still the current research direction to actively restore renal blood flow and reduce or prevent the reperfusion injury. Its pathogenesis includes necrosis and apoptosis of cells, overload of calcium ions and increase of oxygen free radicals ([1]), and increase of inflammatory mediators such as various cytokines and adhesion molecules. Looking for effective multi-target drug prevention and treatment of renal ischemia / reperfusion injury is the basic and clinical research hot spots. Studies have shown that statins not only have a significant lipid-lowering effect, but also