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本文观察了正常豚鼠、在靜息状态下的罹实驗性癲癇病豚鼠以及在发作后的癇病豚鼠血液中氨,血清中游离氨基酸、鉀、鈉离子浓度以及血清蛋白,以比較三类动物之間的异同。往癇病发作后的动物血氨浓度远較正常动物为高,这和前人所得的結果是相似的,但是值得注意的是癇病豚鼠在靜息状态下的血氨浓度比正常动物还低得多。經抗癇药物(天麻浸膏或苯妥英鈉)治疗后又恢复到正常动物的水平。血清內游离氨基酸的情况較为复杂。其中甘氨酸在发作前后的癇病豚鼠均較正常豚鼠为低。谷氨酰胺的合量在癲癇发作后較在靜息状态时有显著升高,而在靜息状态下的病员与正常豚鼠相較无多大区別。其它游离氨基酸三类动物之間的差別不甚显著。血清中鉀、鈉离子的合量三类动物之間均无差异。 癲癇豚鼠血清中γ-球蛋白較正常豚鼠为高。
In this paper, ammonia, serum free amino acids, potassium, sodium ion concentrations and serum proteins in normal guinea pigs, experimental epileptic guinea pigs at rest, and epileptic guinea pigs after the onset of attack were observed in order to compare three animals Similarities and differences between. The blood ammonia concentration of animals after epileptic seizures is much higher than that of normal animals, which is similar to that obtained by the predecessors, but it is noteworthy that the serum ammonia concentration of resting epilepsy guinea pigs at rest is lower than that of normal animals Much more. The antiepileptic drugs (Tianma extract or phenytoin sodium) after treatment returned to normal animal levels. Serum free amino acids are more complicated. Glycine in which epilepsy before and after the onset of guinea pigs were lower than normal guinea pigs. The combined amount of glutamine increased significantly after seizures compared with resting state, while patients in resting state showed no significant difference from normal guinea pigs. The difference between the three other free amino acids is not significant. Serum potassium, sodium ion in the amount of the three animals were no difference between. Epilepsy guinea pig serum γ-globulin higher than normal guinea pigs.