越来越多研究表明,高胰岛素水平会影响结直肠癌的发生和发展,主要是通过胰岛素本身及胰岛素生长因子调控信号通路促进肿瘤分裂增殖,抑制凋亡。脂联素作为脂肪细胞分泌的因子,可以从增强胰岛素敏感性、抑制相关信号通路、抑制血管生成等方面逆转高胰岛素在结直肠癌中的作用。 More and more studies have shown that high insulin levels will affect the occurrence and development of colorectal cancer, mainly through the insulin itself and insulin growth factor regulatory signaling pathway to promote tumor cell division and proliferation, inhibit apoptosis. Adiponectin, as a factor secreted by adipocytes, can reverse the effect of hyperinsulin in colorectal cancer in terms of enhancing insulin sensitivity, inhibiting related signaling pathways and inhibiting angiogenesis.